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Home - Products - Cell Cycle/DNA Damage - Aurora Kinase - Aurora A-IN-10

Aurora A-IN-10

CAS No. 1158838-45-9

Aurora A-IN-10( TC-S 7010 | TC S 7010 | TCS7010 )

Catalog No. M10550 CAS No. 1158838-45-9

A potent, highly selective Aurora A inhibitor with IC50 of 3.4 nM; displays >1,000-fold selectivity over Aurora B (IC50=3.4 uM) or CDKs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Aurora A-IN-10
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, highly selective Aurora A inhibitor with IC50 of 3.4 nM; displays >1,000-fold selectivity over Aurora B (IC50=3.4 uM) or CDKs.
  • Description
    A potent, highly selective Aurora A inhibitor with IC50 of 3.4 nM; displays >1,000-fold selectivity over Aurora B (IC50=3.4 uM) or CDKs; A useful tool compound for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B.
  • In Vitro
    TCS7010 is exceptionally selective Aurora A inhibitors. TCS7010 is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B.
  • In Vivo
    ——
  • Synonyms
    TC-S 7010 | TC S 7010 | TCS7010
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Aurora Kinase
  • Recptor
    Aurora A| Aurora B| Aurora C
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1158838-45-9
  • Formula Weight
    588.075
  • Molecular Formula
    C31H31ClFN7O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1=CC=CC=C1Cl)C2=CC=C(NC3=NC(NC4=CC=C(CC(N5CCN(CC)CC5)=O)C=C4)=NC=C3F)C=C2
  • Chemical Name
    Benzamide, N-(2-chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Aliagas-Martin I, et al. J Med Chem. 2009 May 28;52(10):3300-7.
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